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In clinical studies, Wegovy users experienced a significant weight reduction, losing 14.9% to 17.4% of their initial body weight over 68 weeks, greatly surpassing results typically seen with just diet and exercise

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The American journal of clinical nutrition , 86 (6), 17381744

Yes, when administered by trained medical professionals with proper testing and monitoring

Acknowledgements This work was supported by the Medical Research Council [grant numbers MR/J01186X/1, G0901321, MR/M006301/1], (the third grant is a UK New Investigator Research Grant supporting MJB)