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In addition, SURPASS-4 had the longest duration of the completed studies phase 3 studies tirzepatide trials (Table 1)

Total (AUCIDeg,0 120h,SD) and peak exposure of TRESIBA were on average about 10 25% and 13 27% higher, respectively in subjects with mild to severe renal impairment except subjects with ESRD who showed similar exposure as compared to subjects with normal renal function

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