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Previous research has shown that earlier generation GLP-1s may mute the intensity of the dopamine surge that activates the must-have response when a drug cue is encountered

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Therefore, the -1 subcluster was the only cell subcluster to exhibit a consistent increase in IAPP , PCSK1 , and MAFA in response to liraglutide treatment, suggesting that the effect of liraglutide to increase expression of these cell genes was specific to the -1 subcluster

[DOI] [PubMed] [Google Scholar] 87.Spreafico A, Frediani B, Capperucci C, Leonini A, Gambera D, Ferrata P, et al

de Lamirande E, Gagnon C