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Random-effects models were employed for the pooled analysis, and heterogeneity was evaluated using the I2 statistic

Gonzalez JM, Bowden CL, Katz MM, et al

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No significant heterogeneity among studies ( I 2 = 0%, p =0.84), so the fixed-effects model was used to combine the effect sizes

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Figure 2 In summary, Metabolomics studies have consistently demonstrated that the intestinal metabolite profiles of IBD patients differ significantly from those of healthy controls, including alterations in short-chain fatty acids (SCFAs), bile acids, and tryptophan-derived metabolites, which are repeatedly observed across independent cohorts (177, 178)