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Consistently feeling sad, empty, and hopeless Markedly diminished interest in pleasurable activities Significant weight loss or weight gain Increased or decreased appetite Insomnia or hypersomnia Fatigue or loss of energy Feeling of worthlessness, feeling excessive, or inappropriate guilt Diminished ability to think or concentrate, or indecisiveness Recurrent thoughts of death and suicidal ideation without a specific plan Psychomotor agitation or retardation These symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning

Timeframe Weeks 1-2 Commonly tracked Range-of-motion and functional self-report in case series Notes Reflects symptom-level changes, not structural healing

These GLP-1 drugs are commonly prescribed for diabetes management and weight loss

[4] Tuchman, M., & Mueser, T

That is usually when the foundation starts wobbling

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