It can be a skin irritant , so much so that it is a well-known counterirritant for muscle pains creating mild surface irritation to make things better in the deeper layers
Cliton NJ 681 , 259280, (2011)
And apart from its transparency about test results (which are current), it has a couple of other qualities that contribute to its being a highly effective berberine supplement: It comes in 500mg capsules, so you can easily adjust your dosage from the low end to the high end of the 500-1,500mg range used in successful research
5 mg bottle $125 Active in the brain, this peptide helps modulate the functions of key areas of the brain like the hypothalamus and pineal glands
Cagrilintide: A long-acting amylin analog for the treatment of obesity
Short-term use, as in gout, generally much better tolerated than long-term use