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Loss of disc height, hydration and proteoglycans has also been reported after experimental endplate perforation in pigs and endplate fracture in rabbit spinal explants

While the underlying cause of the disease is not clearly understood, depletion of dopamine-producing cells may be exacerbated by oxidative stress, inflammation, and mitochondrial dysfunction

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whether there is a rate-limiting pathway or synergistic/antagonistic crosstalk across cell types and pathological conditions has not been systematically evaluated