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As with any protocol, a provider consultation determines whether and how often it fits your situation

However, as a GLP-1 medicine it slows gastric emptying, which can affect how quickly other oral medicines such as fluoxetine are absorbed, and the tablet must be taken on an empty stomach with a set routine, so the timing of your other medicines needs planning

While highly effective, the need for weekly injections can be a deterrent for some individuals due to needle aversion or simply the inconvenience of administration

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In the fasted state, SIRT1 deacetylates PGC1 and increases its activity [46]