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Genet 17 , 206210 (1997)

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Across phenotypes, our data indicate an association between rs1800437 and tirzepatide treatment for both the vomiting and nausea phenotypes, and potentially constipation, but the variant does not seem to influence efficacy ( P = 0.73

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the bulky 2-naphthyl side chain is essential for potency and selectivity D-Phenylalanine (position 4):Contributes to metabolic stability and receptor-binding specificity