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TNF-, a proinflammatory cytokine, promotes immune cell recruitment and cell death by inducing the expression of cytokines, chemokines, adhesion molecules, cyclooxygenase-2, and inducible nitric oxide synthase or by activating signaling pathways such as the NF-B, STAT, and PPARs pathways

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Cobanoglu U, Demir H, Duran M, et al

2019;181:R211R234

and 150 mg/kg s.c.)