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Clinical significance of the SLC33A1 encoded transporter is evident from the fact that mutation in the gene are associated with a lethal disorder identified as Huppke-Brendel syndrome (HPBDS)

Ann Neurol 1994;36, 747-751

They are in most instances indicative of elevated blood circulation and skin repair

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Because obesity is considered a long-term, relapsing metabolic condition, ongoing treatment is often necessary to maintain results