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The treatment works by mimicking a natural hormone that controls hunger and glucose levels, supporting long-term weight management

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Mice were habituated to dropping into the target hole the day before the first training session

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These ligand-free complexes share a similar intracellular architecture to those bound by endogenous peptides, in which, the G s protein alone directly opens the intracellular binding cavity and rewires the extracellular orthosteric pocket to stabilize the receptor in a state unseen before

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