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Peptide therapeutics are not naturally suited for oral administration because of their inherently low gastrointestinal permeability, high susceptibility to degradation by gastrointestinal and serum proteases, and rapid renal clearance 8

doi: 10.1016/j.molmet.2018.03.011 23 KsterAChaoYBMosiorMFordAGonzalez-DeWhittPAHaleJEet al

After reconstitution, concentration is (vial mg) (mL of bac water added) = mg/mL

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Given the rarity of the disease, it is important to accumulate new evidence concerning diagnostic features, prognosis, and clinical outcome