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Key points The choice of preclinical models should align with the current steatotic liver disease definition: cardiometabolic risk factors must be appropriately recapitulated to place metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH)-related hepatocellular carcinoma (HCC) models in the right metabolic context

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Glutathione is required to regulate the formation of native disulfide bonds within proteins entering the secretory pathway*