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The dosing information presented here is derived exclusively from clinical trial protocols and published research literature, and should not be interpreted as prescribing advice

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-Glutamyl cysteine synthetase is the rate-limiting enzyme in the de novo biosynthesis of GSH from cysteine, glutamate and glycine 23

Furthermore, oxidative stress activates the release of HMGB1 signal transduction in keratinocytes by decreasing the level of melanogenetic molecules (including gp100) and inducing apoptosis

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