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Non-use of validated assessment tools (e.g., stable 13C-labeled fatty acid breath test) and reliance on self-reported symptoms instead of validated GI disorder symptom indices are also limitations

This boosts endurance, increases fat oxidation, and improves overall workout performance, making pre-workout the best time for fitness-focused users

42 Health care providers should be cognizant of this potential risk and monitor patients appropriately

Reducing the dose means reduced appetite suppression, which can lead to weight regain if eating habits slip

However, interpreting the direct impact of gut-derived neurotransmitters on CNS function requires caution, as most peripheral neurotransmitters cannot freely cross the BBB under homeostatic conditions [187]

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