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All these risk factors have a common characteristic, they are associated with a continuous state of oxidative stress and inflammation, excessive production of free radicals (reactive oxygen and nitrogen species) and endothelial cell dysfunction leading to cardiovascular disease and respiratory failure

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Subcutaneous administration: 250-500mcg daily or every other day for more consistent systemic levels

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Application frequency for topical protocols is typically once or twice daily, applied to cleansed skin at the target area

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