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The potential value of vitamin D in treating uterine fibroids primarily stems from its dual properties of antioxidant activity and hormone regulation

However, the distribution of Vitamin D and its metabolites is tissue-specific, and local concentrations or biological activity may not correlate directly with serum levels, indicating that serum 25(OH)D alone may not fully reflect systemic Vitamin D sufficiency in all contexts [92, 93]

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The mammalian lipoxygenase family includes six distinct isoforms (ALOXE3, ALOX5, ALOX12, ALOX12B, ALOX15, and ALOX15B), and the researchers found that only the absence of ALOX12 significantly reduced ferroptosis

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