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It stimulates the pituitary gland to release growth hormone in a physiologic, pulsatile manner

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[3] [4] The combined effect produces substantial weight losstypically about 15% of body weight over 68 weeks with semaglutide 2.4 mg (Wegovy), and up to 22% with tirzepatide 15 mg (Zepbound)

[15] [8] In March 2024, the FDA further approved Wegovy to reduce the risk of major adverse cardiovascular events in adults with established cardiovascular disease and either obesity or overweight