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462 Inhibition of the NF-B signaling pathway leads to the decreased production of inflammatory mediators, including adhesion molecules and chemokines, which are crucial for the recruitment of immune cells to sites of inflammation

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Under these conditions, the product remains stable for extended periods

Grading of the evidence The certainty of the evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation approach developed for network meta-analyses (Reference Brignardello-Petersen, Bonner and Alexander20)

6 Unfortunately, a systematic review of randomized controlled trials in Parkinsons patients found CoQ10 supplementation did not improve symptoms or slow the decline of the disease