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There are two main theories behind the treatment strategies

If the solution turns yellow, cloudy, or develops floating particles, it has degraded or become contaminated

doi: 10.1113/expphysiol.2009.048330 80 WittwerEDLiuZWarnerNDSchroederDRNadeauAMAllenARet al

You add too little, and the solution becomes so concentrated that measuring a precise 2.5mg dose with an insulin syringe becomes nearly impossible

It is the reason the FDA's career scientists spent months reviewing the evidence and arrived at a unanimous negative recommendation before a panel whose composition may not be positioned to weigh that evidence independently