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Mutant OPTN promotes the expression of downstream target genes of NF-B, such as p53 and proapoptotic proteins, to induce cell death by triggering p53-dependent apoptosis
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Studies have examined its relationship with nitric oxide signaling, growth-factor communication, angiogenesis-related mechanisms, and cellular migration in a range of experimental models.,, Angiogenesis (Blood Vessel Formation) Research One area of investigation involves angiogenesis, the biological process associated with blood vessel formation
From signalling pathways to targeted therapies: unravelling glioblastomas secrets and harnessing two decades of progress
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