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The follicle is not dead

From a histological point of view, atypical tumor glands, constituted by neoplastic epithelial cells, occur in dense desmoplastic stroma, a proper physical barrier promoting tumor growth and progression and contributing to hamper anti-tumoral response and therapeutics delivery [11,12,13,14]

Those are telogen hairs completing their cycle

In contrast, cells with lower senescence burden may have less FOXO4p53 dependence, or may buffer p53 relocalization through other regulators, which might explain the limited apoptosis in younger cultures compared to aged cell cultures

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