Ding L, Huwyler F, Long F, Yang W, Binz J, Wernle K, et al
Largely across society, we dont accept obesity as a long-term chronic disease, and were still looking for quick fixes and quick solutions where thats not the reality of the biology and disease process
Plus, they can trigger unwelcome side effects such as nausea, diarrhea and fatigue
GLP-1 receptor agonists work through several mechanisms: they enhance insulin secretion when blood glucose levels are elevated, suppress glucagon release (which reduces glucose production by the liver), slow gastric emptying, and promote satiety through effects on appetite centres in the brain
Animal model studies have suggested that GLP-1RAs may cause pancreatitis and exocrine dysplasia, but in the large RCTs and a meta-analysis, GLP-1RAs did not increase the risk of pancreatitis or pancreatic cancer [82,83]
Ultimately, your healthcare provider will help determine if you are a good candidate for weight loss medications based on things like your age, weight, personal and family health history, any underlying conditions, and more
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