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Acknowledgements This work was supported, in part, by the European Association for the Study of the Liver, by grants from Medica Sur Clinic and Foundation (to N.M.-S.), the Fondo Nacional de Desarrollo Cientfico y Tecnolgico (FONDECYT, grant 1130303 to J.-F.M.), the Italian Agency of Drugs (AIFA, grant MRAR08P011 to P.P.) and research grants DK101793 and DK106249 (to D.Q.-H.W.), both from the NIH (US Public Health Service)