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RNA sequencing analysis revealed that palbociclib treatment induces features previously reported in senescence cells 40 , with top upregulated Enricher terms being senescence and autophagy, cytokines and inflammatory response, PI3K-AKT-mTOR survival pathway and TGF-beta regulation of extracellular matrix (Fig

This scoring system allowed for semi-quantitative evaluation of cartilage integrity based on macroscopic features such as softening, fibrillation, erosion, ulceration, and complete cartilage loss [1]

doi: 10.2147/DDDT.S411211 272

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