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Megaloblastic anemia is one such deficiency, a macrocytic anemia that causes bone marrow to create very large red blood cells

It also helps reduce oxidative stress, which can contribute to uneven skin tone and pigmentation

"Leuco" (white) and "derma" (skin) together describe leucoderma, emphasizing the abnormal whiteness of affected areas

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To determine the amount of NFT required after its initial addition and a washout phase to maintain elevated glutathione levels, cells were pretreated with 20 M NFT for 48 h, maintained in NFT-free medium for 24 h, and subsequently treated with varying concentrations of NFT over 24 h

The exact mechanisms through which glutathione regulates brain metabolism are not well understood