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If unplanned pregnancy occurs despite contraception, follow the guidance about stopping medication immediately and contacting your providers for appropriate prenatal care

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Professor James Collip was a clinical biochemist who helped Banting and Best to refine the process of producing pure insulin extract

Acknowledgements This work was supported by Funding of the"famous doctors"project of the support plan for the talents of Xingdian (No.RLMY20220005), The scientific and technological innovation team of Kunming Medical University (CXTD202209), Clinical Collaboration Project of Traditional Chinese and Western Medicine for Major Difficult Diseases of Yunnan Province (300073)

Its presence in the glyoxalase system is fundamental to DNA and RNA nucleotide reduction