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Although higher plants do not appear to require selenium for survival, they can incorporate it nonspecifically into sulfur-containing molecules when the mineral is present in the soil (1)

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This phase is characterized by the presence of autoantibodies, namely anti-citrullinated protein antibodies (ACPAs) and Fc domain-recognizing rheumatoid factors (RFs) ( + T cells, and macrophages, along with early activation of stromal cells