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, gravitational, centrifugal, etc.) in the presence or the absence of 3D matrices ( in vitro preclinical models to clinical applications ( In the context of in vitro models, a significant milestone is marked by the development of organ-on-chip (OoC) technology since they offer superior control over the cellular microenvironment, enable dynamic perfusion and mechanical stimulation, support real-time monitoring, and allow multi-tissue integration with higher reproducibility compared to organoids and spheroids (40)
Foitzik, K., Hoting, E., Frster, T., Pertile, P
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This review presents advances of NAD + in the pathophysiology of fatty liver disease, focusing on the biological roles of NAD + in liver lipid accumulation, oxidative stress, endoplasmic reticulum stress (ERS), inflammation, autophagy, and liver fibrosis during the development of fatty liver disease
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