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Therefore, the GLP-1-induced excitation of MCs, probably via inhibition of voltage-dependent potassium channel conductance and enhancement of glutamatergic neurotransmission, could lead to changed excitability of higher olfactory cortical as well as hypothalamic regions to change metabolic states

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STEP 3: Enhanced Lifestyle Intervention STEP 3 combined semaglutide with intensive behavioral therapy (30 counseling sessions over 68 weeks plus an initial 8-week low-calorie diet)

95% CI 1.202.77), and basal insulin (IRR, 2.58

Gibbons C., J

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