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Primary outcome (major adverse cardiovascular events) occurred in 12.0 percent of the semaglutide group versus 13.8 percent with placebo This corresponds to a 14 percent relative reduction in risk Absolute reduction in risk was 2.0 percent over 3 years Number needed to treat to prevent one event: 50 patients Nonfatal heart attacks occurred in 4.0 percent with semaglutide versus 5.2 percent with placebo Stroke and death from cardiovascular causes were slightly lower but not statistically different Kidney outcomes were directionally better with semaglutide but not statistically significant Additional benefits with oral semaglutide Lower average blood sugar (hemoglobin A1c reduced by 0.71 percent vs

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As research continues, the list of potential applications grows, suggesting these medications may eventually be viewed less as weight loss drugs and more as metabolic health optimizers with wide-ranging benefits