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Other indicators of insufficient dosing include: No change in body weight after four or more weeks at the same dose Hunger returning well before your next weekly injection, especially if it returns within two to three days No change in blood sugar levels for individuals using tirzepatide for type 2 diabetes Food noise remaining as loud as it was before starting the medication If you are reading this because you drew 50 units from a 5 mg/mL vial and are wondering why you are not losing weight on tirzepatide , the answer may simply be that 2.5 mg is the initiation dose, not a weight-loss dose