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These drugs are still being tested in large clinical trials
The desired effects of this medicine may not be achieved if it is taken along with alcohol
Weight loss drugs in clinical development GLP-1 related drugs The mechanism of action of GLP-1 agonists for weight loss is multi-factorial, and the improvement of intestinal, brain and systemic insulin sensitivity all contribute to the efficacy
Neurological symptoms associated with B12 deficiencysuch as paraesthesia, ataxia, or cognitive impairmentrequire urgent treatment with more frequent injections (1mg on alternate days initially) to prevent irreversible nerve damage
Out-of-pocket costs are the strongest predictor of abandonment: High OOP costs drive non-adherence, especially in obesity, where coverage is limited and stigma persists
![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
