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The mechanism of metabolic acidosis and 5-oxoprolinuria is the following: decreased levels of cellular glutathione lead to decreased feed-back inhibition of -glutamylcysteine synthetase

[DOI] [PMC free article] [PubMed] [Google Scholar] Cao X

While GLP-1 medications help with weight loss and metabolic health, they can sometimes speed up muscle loss, skin thinning, and collagen decline

10.1016/j.ejphar.2017.02.015 42

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