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Effects of linagliptin treatment on basal insulin and glucagon secretion of human islets varied between diabetic and non-diabetic donors Previous studies have shown beneficial effects of linagliptin on cell survival and function in islets isolated from normal human donors 28

Subsequently, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted to elucidate the signaling pathways associated with the differentially expressed proteins