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The authors acknowledge support from the National Institutes of Health (R01-HL125654 to S.B.N

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Festoff BW, Sajja RK, van Dreden P, Cucullo L (2016) HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimers disease

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They have been studied in clinical trials lasting over a year, showing sustained benefits with no significant long-term safety concerns