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[2] Clinical Trials Doses Across multiple clinical trials, retatrutide was evaluated in varying doses to determine optimal therapeutic windows for both weight loss and glycemic control

PMID 16609979

Achieving systemic exposure that exceeds an equivalent injectable dose is uncommon for oral biologic delivery technologies, many of which have historically produced substantially lower exposure than subcutaneous administration

Those in the oral semaglutide group at the end of 64 weeks lost an average of 13.6%