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The high pressure equipment used to induce high shear force requires to disrupt the cell structure

Vukojevi, J., Milavi, M., Perovi, D., Ili, S., ili, A

The oral route exposes the GI tract to higher local concentrations of semaglutide, which can trigger more nausea, vomiting, and diarrhea

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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)

"AOD9604 - Important Clarifications" (PDF)