Recent evidence from the STEP-HFpEF and STEP-HFpEF-DM trials provides the first robust data supporting the efficacy of GLP-1 RAs, specifically semaglutide, in improving the quality of life in obese patients with HFpEF
This constant engagement helps in compliance to treatment and safety particularly during the early stages of treatment
Essentially, on the standard weekly dosing model, the amount of incretin circulating on the last couple of days is quite a bit lower than the rest of the time
Specifically, antagonizing NMDA receptors in the brainstem has been associated with an increase in short-term food intake 6,7
These foods can also cause blood sugar spikes and crashes that leave you feeling tired and hungry again faster
However, anecdotal reports from some patients suggest changes in sexual function during treatment, which may be attributed to several indirect mechanisms rather than a direct pharmacological effect of the medication itself