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The paracellular route takes the peptide between the epithelial cells, squeezing through the narrow spaces where cells meet

Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats

Systemic and gut-selective inhibition of DPP-4 activity improves lipid tolerance and reduces TG production in young RC-fed mice

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doi: 10.1186/s12967-020-02277-0 92

Ms all del efecto sobre el EEG y el sueo, la revisin de Graf y Kastin documenta que el material tipo DSIP se distribuye en cerebro, rganos perifricos y plasma, y se ha asociado con la modulacin de niveles de neurotransmisores, patrones circadianos/locomotores y niveles hormonales (incluidos ejes relacionados con el HPA), con una curva de respuesta a dosis y tiempo de tipo no lineal (forma de U) (PMID 6145137)