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In rats, the oral dose found to be effective was 10g/kg, or 1.6g/kg

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doi: 10.1016/0026-0495(81)90052-4 61 FazeliPKLawsonEAPrabhakaranRMillerKKDonohoDAClemmonsDRet al

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Treatment courses often extend for at least three to six months before meaningful cosmetic changes might be appreciated, and continued application may be required to maintain any gains