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The superoxide-mediated release of Fe 2 associated with mitochondrial aconitase inactivation has been shown to be a signicant source of OH radical formation through Fenton chemistry
MT-1 (afamelanotide): Selective for MC1R (melanin production receptor) 13-residue linear peptide FDA-approved for EPP Side effects: typically headache, fatigue, nausea generally mild More expensive per dose, more conservative tanning MT-2: Activates MC1R, MC3R, MC4R, MC5R broader receptor profile 7-residue cyclic peptide (smaller) Not FDA-approved Side effects: nausea, flushing, libido effects (MC4R activation), potential melanoma concerns with new moles Cheaper per dose, faster/darker tanning For tanning users prioritizing safety profile and tolerability, MT-1 is the more documented option despite higher per-mg cost
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doi: 10.1186/1477-7827-11-48 18 HerwigRKnollCPlanyavskyMPourbiabanyAGreilbergerJBennettKL
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