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GLP-1 receptor agonists work by mimicking the action of this hormone , which is released from the intestine in response to food intake

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If it is clear that there is a fear of needles, or if good injection technique may be an issue (e.g., due to limitations with manual dexterity or lack of injection training opportunities), then oral semaglutide would seem a reasonable approach

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In other words, Cagrilintide is often treated as a second-step optimisation peptide , layered on top of a GLP-1 foundation rather than replacing it