While research on this compound is still ongoing, preliminary studies have provided insights into its potential therapeutic applications and benefits
Despite its importance, our body cant produce vitamin B12 on its own
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Vitamin B12 is an essential component of several enzymes involved in normal metabolism
Clinical trials have demonstrated significant weight loss (mean 1015% body weight reduction) in individuals with obesity when combined with lifestyle interventions [1] [5]
What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect
