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When released in response to food intake, GLP-1 helps to: Increase insulin secretion Decrease glucagon secretion Slow gastric emptying Promote satiety By activating GLP-1 receptors in the brain and gastrointestinal tract, these medications help individuals feel fuller for longer periods, ultimately leading to reduced caloric intake and weight loss

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The added thermogenic and hepatic-lipid effect is hypothesised to account for the larger weight-loss magnitude observed in Phase 2 compared with dual GIP/GLP-1 agonism [1]

Thyroid function tests should be monitored periodically (typically every 6-12 months or when symptoms suggest over- or under-replacement), and levothyroxine doses adjusted accordingly

49 JonesBBuenaventuraTKandaNChabosseauPOwenBMScottRet al

however, in breast cancers, the relationship provides some relevance [33]