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As the first anti-obesity drug targeting multiple receptors, tirzepatide (Zepbound, Eli Lilly), a dual GIPR/GLP-1R agonist, was approved by the FDA in 2022

LDL cholesterol was primarily calculated using the Friedewald formula (LDL = Total Cholesterol HDL [Triglycerides/5], mg/dL)

14 The QUALITY trial added enobosarm, a medication that activates muscle- and bone-building signals similar to testosterone but only in those tissues, to semaglutide in older adults with obesity

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and Luo, Y., 2019