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By contrast, 7-hydroxymitragynine (7-OH), while also labeled a partial agonist, is highly potent at the same receptors and produces dose-dependent respiratory depression and dependence signals in animal studies
Herkert, D., Vijayakumar, P., Luo, J., Schwartz, J
This ingredient not only brightens dull skin but also reduces age spots and hyperpigmentation effectively
After further examination of the included papers, the literature searches yielded a final result of 29 studies considered as relevant for the systematic review and 21 studies suitable for the meta-analyses
A pooled analysis of clinical trials showed a slightly elevated but not statistically significant risk