People who dont produce enough intrinsic factor can become deficient
Even so, early clinical data have drawn significant attention from researchers and clinicians
GH mediates its functions directly through its receptor (GHR) or indirectly via insulin-like growth factor 1 (IGF1) (Yang et al., 2008)
When deficient, animals can have reduced appetite and growth rates, ill thrift, infertility, and reduced wool and milk production
Multiple clinical trialsincluding SUSTAIN-6 (semaglutide) and REWIND (dulaglutide)showed significant reductions in major adverse cardiovascular events (MACE) such as: Heart attack Stroke Cardiovascular death This benefit appears to be independent of weight loss , suggesting direct protective effects on the arteries, blood pressure, and cholesterol metabolism
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