One of those dual agonists, tirzepatide (Mounjaro/Zepbound, Eli Lilly), was associated with a mean 14.7% weight loss for adults with overweight or obesity and type 2 diabetes in the SURMOUNT-2 trial compared with a 3.2% weight loss with placebo
More importantly, transcriptomic analysis showed that tirzepatide upregulated gene programs related to thermogenesis and lipid metabolism, including increased expression of "browning" markers such as PGC-1 and UCP1-indicating that it converts energy-storing white fat into thermogenic beige/brown fat
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& Miyashita, T
Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): A substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial
Second, the selection of high-altitude populations was mainly concentrated around genomic regions of oxygen sensing, transport, and delivery, along with protection from other altitude-associated environmental factors like high UV radiation and cold
